Published research

2014

2013

  • Hasegawa Y, Daitoku Y, Sekiguchi K, Tanimoto Y, Iijima S, Mizuno S, Kajiwara N, Ema M, Miwa Y, Mekada K, Yoshiki A, Takahashi S, Sugiyama F, Yagami K. Novel ROSA26 Cre-reporter knock-in C57BL/6N mice exhibiting green emission before and red emission after Cre-mediated recombination. Exp Anim 62:295-304. (2013)
  • Kudo T, Sato T, Hagiwara K, Kozuma Y, Yamaguchi T, Ikehara Y, Hamada M, Matsumoto K, Ema M, Murata S, Ohkohchi N, Narimatsu H, Takahashi S. C1galt1-deficient mice exhibit thrombocytopenia due to abnormal terminal differentiation of megakaryocytes. Blood. 122:1649-1657. (2013)
  • Nishimoto M, Katano M, Yamagishi T, Hishida T, Kamon M, Suzuki A, Hirasaki M, Nabeshima Y, Nabeshima Y, Katsura Y, Satta Y, Deakin JE, Graves JA, Kuroki Y, Ono R, Ishino F, Ema M, Takahashi S, Kato H, Okuda A. In vivo function and evolution of the eutherian-specific pluripotency marker UTF1. PLoS One. 8:e68119. (2013)
  • Yoshida T, Omatsu T, Saito A, Katakai Y, Iwasaki Y, Kurosawa T, Hamano M, Higashino A, Nakamura S, Takasaki T, Yasutomi Y, Kurane I, Akari H. Dynamics of cellular immune responses in the acute phase of dengue virus infection. Arch Virol. 158:1209-1220. (2013)
  • Lebrun C., Avci HX., Wehrlé R., Doulazmi M., Jaudon F., Morel MP., Rivals I.,Ema M., Schmidt S., Sotelo C., Vodjdani G., Dusart I. Klf9 is necessary and sufficient for Purkinje cell survival in organotypic culture. Mol Cell Neurosci. 54:9-21. (2013)
  • Moi ML, Omatsu T, Hirayama T, Nakamura S, Katakai Y, Yoshida T, Saito A, Tajima S, Ito M, Takasaki T, Akari H, Kurane I. Presence of viral genome in urine and development of hematuria and pathological changes in kidneys in common marmoset (Callithrix jacchus) after inoculation with dengue virus. Pathogen. 2:357-363. (2013)
  • Okumura N, Koizumi N, Kay EP, Ueno M, Sakamoto Y, Nakamura S, Hamuro J, Kinoshita S. The ROCK inhibitor eye drop accelerates corneal endothelium wound healing. Invest Ophthalmol Vis Sci. 54:2493-2502. (2013)
  • Katsumata T, Oishi H, Sekiguchi Y, Nagasaki H, Daassi D, Tai PH, Ema M, Kudo T, Takahashi S. Bioluminescence imaging of β cells and intrahepatic insulin gene activity under normal and pathological conditions. PLoS One. 8:e60411. (2013)
  • Fujishiro SH., Nakano K., Mizukami Y., Azami T., Arai Y., Matsunari H., Ishino R., Nishimura T., Watanabe M., Abe T., Furukawa Y., Umeyama K., Yamanaka S., Ema M., Nagashima H., Hanazono Y. Generation of Naive-like Porcine Induced Pluripotent Stem Cells Capable of Contributing to Embryonic and Fetal Development. Stem Cells Dev. 22:473-482. (2013)

2012

  • Oishi H, Itoh S, Matsumoto K, Ishitobi H, Suzuki R, Ema M, Kojima T, Uchida K, Kato M, Miyata T, Takahashi S, Delayed cutaneous wound healing in Fam129b/Minerva-deficient mice. J. Biochem. 152:549-555. (2012)
  • Omatsu T, Moi ML, Takasaki T, Nakamura S, Katakai Y, Tajima S, Ito M, Yoshida T, Saito A, Akari H, Kurane I. Changes in hematological and serum biochemical parameters in common marmosets (Callithrix jacchus) after inoculation with dengue virus. J Med Primatol. 41:289-296. (2012)
  • Sugimoto C, Nakamura S, Hagen SI, Tsunetsugu-Yokota Y, Villinger F, Ansari AA, Suzuki Y, Yamamoto N, Nagai Y, Picker LJ, Mori K. Glycosylation of simian immunodeficiency virus influences immune-tissue targeting during primary infection, leading to immunodeficiency or viral control. J Virol. 86:9323-9336. (2012)
  • Nishimura M, Nakamura S, Kimura N, Liu L, Suzuki T, Tooyama I. Age-related modulation of γ-secretase activity in non-human primate brains. J Neurochem. 123:21-28. (2012)
  • Takase H., Matsumoto K., Yamadera R., Kubota Y., Otsu A., Suzuki R., Ishitobi H., Mochizuki H., Kojima T., Takano S., Uchida K., Takahashi S., Ema M. Genome-wide identification of endothelial cell-enriched genes in the mouse embryo. Blood 120:914-923. (2012)
  • Matsumoto K., Azami T., Otsu A., Takase H., Ishitobi H., Tanaka J., Miwa Y., Takahashi S., Ema M. Study of normal and pathological blood vessel morphogenesis in Flt1-tdsRed BAC Tg mice. Genesis. 50:561-571. (2012)
  • Arikata M, Itoh Y, Okamatsu M, Maeda T, Shiina T, Tanaka K, Suzuki S, Nakayama M, Sakoda Y, Ishigaki H, Takada A, Ishida H, Soda K, Pham VL, Tsuchiya H, Nakamura S, Torii R, Shimizu T, Inoko H, Ohkubo I, Kida H, Ogasawara K. Memory immune responses against pandemic (H1N1) 2009 influenza virus induced by a whole particle vaccine in cynomolgus monkeys carrying Mafa-A1*052:02. PLoS One. 7:e37220. (2012)
  • Sano K., Katsuta O., Shirae S., Kubota Y., Ema M., Suda T., Nakamura M., Hirashima M. Flt1 and Flk1 mediate regulation of intraocular pressure and their double heterozygosity causes the buphthalmia in mice. Biochem Biophys Res Commun. 420:422-427 (2012)
  • Avci HX., Lebrun C., Wehrlé R., Doulazmi M., Chatonnet F., Morel MP.,Ema M., Vodjdani G., Sotelo C., Flamant F., Dusart I. Thyroid hormone triggers the developmental loss of axonal regenerative capacity via thyroid hormone receptor α1 and kruppel-like factor 9 in Purkinje cells. Proc Natl Acad Sci U S A. 109:14206-14211 (2012)
  • Okahara-Narita J, Umeda R, Nakamura S, Mori T, Noce T, Torii R. Induction of pluripotent stem cells from fetal and adult cynomolgus monkey fibroblasts using four human transcription factors. Primates. 53:205-213. (2012)
  • Nakamura S, Tsuchiya H, Okahara N, Nakagawa T, Ohara N, Yamamoto H, Li T, Takeda N, Ogasawara K, Torii R. Epidemiology of Hepatitis E Virus in Indoor-Captive Cynomolgus Monkey Colony. J Vet Med Sci. 57;279-283. (2012)
  • Ueda M, Ageyama N, Nakamura S, Nakamura M, Chambers J, Misumi Y, Mizuguchi M, Shinriki S, Kawahara S, Tasaki M, Jono H, Obayashi K, Sasaki E, Une Y, Ando Y. Aged vervet monkeys developing transthyretin amyloidosis with the human disease-causing Ile122 allele: A valid pathological model of the human disease. Lab Invest. 92:474-484. (2012)
  • Yoshida T, Omatsu T, Saito A, Katakai Y, Iwasaki Y, Iijima S, Kurosawa T, Hamano M, Nakamura S, Takasaki T, Yasutomi Y, Kurane I, Akari H. CD16 positive natural killer cells play a limited role against primary dengue virus infection in tamarins. Arch Virol. 157:363-368. (2012)
  • Morichika J, Iwatani C, Tsuchiya H, Nakamura S, Sankai T, Torii R. Triplet pregnancy in a cynomolgus monkey (Macaca fascicularis) after double embryo transfer. Comp Med. 62:69-72. (2012)
  • Toyoshima Y, Sekiguchi S, Negishi T, Nakamura S, Ihara T, Ishii Y, Kyuwa S, Yoshikawa Y, Takahashi K. Differentiation of neural cells in fetal cerebral cortex of cynomolgus monkeys (Macaca fascicularis). Comp Med. 62:53-60. (2012)

2011

  • Kuroda T, Murayama A, Katagiri N, Ohta Y, Fujita E, Masumoto H, Ema M, Takahashi S, Kimura K, Yanagisawa J. RNA content in the nucleolus alters p53 acetylation via MYBBP1A. EMBO J. 30, 1054-1066 (2011)
  • Nakamura S, Ueda M, Ageyama N, Ando Y, Torii R. : Transthyretin amyloidosis in aged vervet monkeys, as a candidate for the spontaneous animal model of senile systemic amyloidosis. (Sarantseva S. ed.) INTECH, (Rijeka, Croatia), 181-190, (2011)
  • Sato T., Kudo T., Ikehara Y., Ogawa H., Hirano T., Kiyohara K., Hagiwara K., Togayachi A., Ema M., Takahashi S., Kimata K., Watanabe H., Narimatsu H.: Chondroitin sulfate N-acetylgalactosaminyltransferase 1 is necessary for normal endochondral ossification and aggrecan metabolism. J Biol Chem. 286:5803-5812. (2011)
  • Kumadaki S., Karasawa T., Matsuzaka T., Ema M., Nakagawa Y., Nakakuki M., Saito R., Yahagi N., Iwasaki H., Sone H., Takekoshi K., Yatoh S., Kobayashi K., Takahashi A., Suzuki H., Takahashi S., Yamada N., Shimano H. Inhibition of Ubiquitin ligase F-box and WD repeat domain-containing 7{alpha} (Fbw7{alpha}) causes hepatosteatosis through the Kruppel-like factor 5 (KLF5)/PPAR{gamma}2 pathway, but not SREBP-1c in mice. J Biol Chem. 286, 40835-40846 (2011)
  • Hishida T, Nozaki Y, Nakachi Y, Mizuno Y, Okazaki Y, Ema M, Takahashi S, Nishimoto M, Okuda A. Indefinite Self-Renewal of ESCs through Myc/Max Transcriptional Complex-Independent Mechanisms. Cell Stem Cell 9, 37-49 (2011)
  • Kajiro M, Tsuchiya M, Kawabe Y, Furumai R, Iwasaki N, Hayashi Y, Katano M, Nakajima Y, Goto N, Watanabe T, Murayama A, Oishi H, Ema M, Takahashi S, Kishimoto H, Yanagisawa J. The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis. PLoS One. 6(10):e25871 (2011)
  • Omatsu T, Moi ML, Hirayama T, Takasaki T, Nakamura S, Tajima S, Ito M, Yoshida T, Saito A, Katakai Y, Akari H, Kurane I. Common marmoset (Callithrix jacchus) as a primate model of dengue virus infection: development of high levels of viraemia and demonstration of protective immunity. J Gen Virol. 92:2272-2280. (2011)
  • Kubota Y, Takubo K, Hirashima M, Nagoshi N, Kishi K, Okuno Y, Nakamura-Ishizu A, Sano K. Murakami M, Ema M, Omatsu Y, Takahashi S, Nagasawa T, Shibuya M, Okano H, Suda T. Isolation and function of tissue resident vascular precursors marked by myelin protein zero. J. Exp. Med. 208, 949-960 (2011)
  • Ishitobi H, Wakamatsu A, Liu F, Azami T, Hamada M, Matsumoto K, Kataoka H, Kobayashi M, Choi K, Nishikawa S, -I, Takahashi S, Ema M. Molecular basis for Flk1 expression in hemato-cardiovascular progenitors in the mouse. Development 138, 5357-5368 (2011)

2010

  • Verma M., Asakura Y., Hirai H., Watanabe S., Tastad C., Fong GH., Ema M., Call JA,, Lowe DA,, Asakura A.: Flt-1 haploinsufficiency ameliorates muscular dystrophy phenotype by developmentally increased vasculature in mdx mice. Hum Mol Genet. 19: 4145-4159. (2010)
  • Ishitobi H., Matsumoto K., Azami T., Itoh F., Itoh S., Takahashi S., Ema M.: Flk1-GFP BAC Tg mice: an animal model for the study of blood vessel development. Exp. Animals, 59: 615-622. (2010)
  • Ushitora M, Sakurai F, Yamaguchi T, Nakamura S, Kondoh M, Yagi K, Kawabata K, Mizuguchi H. Prevention of hepatic ischemia-reperfusion injury by pre-administration of catalase-expressing adenovirus vectors. J Control Release. 142:431-437. (2010)
  • Shimozawa N, Nakamura S, Takahashi I, Hatori M, Sankai T. Characterization of a novel embryonic stem cell line from an intracytoplasmic sperm injection-derived blastocyst in the African green monkey. Reproduction. 139:565-573. (2010)
  • Kojima T., Hirota Y., Ema M., Takahashi S., Miyoshi I., Okano H., Sawamoto K.: Subventricular zone-derived neural progenitor cells migrate along a blood vessel scaffold toward the post-stroke striatum. Stem Cells, 28:545-554. (2010)