中村 紳一朗

准教授(獣医師)
経歴
平成4年3月 麻布大学 獣医学部 獣医学科 卒業
平成8年3月 東京大学 農学生命科学 獣医学 専攻 博士課程 修了
平成10年4月 日本獣医畜産大学 助手
平成13年4月 日本獣医畜産大学 講師
平成13年4月 University of Wisconsin, Madison, Wsiconsin National Primate Center, Research Associate
平成14年4月 National Institute of Health, National Institutes of Dental Craniofacial Research, Postdoctral fellow
平成15年4月 日本獣医畜産大学 復職
平成17年4月 社団法人予防衛生協会 主任研究員
平成19年4月 滋賀医科大学動物生命科学研究センター 准教授
研究テーマ

ウイルスベクターを用いたアルツハイマー病のカニクイザルモデルの作製、カニクイザルを用いた子宮内膜症の免疫学的研究

論文一覧
2016
  • Sasaki K, Nakamura T, Okamoto I, Yabuta Y, Iwatani C, Tsuchiya H, Seita Y, Nakamura S, Shiraki N, Takakuwa T, Yamamoto T, Saitou M. The Germ Cell Fate of Cynomolgus Monkeys Is Specified in the Nascent Amnion. Dev Cell. 39(2):169-185 (2016)
  • Hara H, Ono F, Nakamura S, Matsumoto SE, Jin H, Hattori N, Tabira T. An Oral Aβ Vaccine Using a Recombinant Adeno-Associated Virus Vector in Aged Monkeys: Reduction in Plaque Amyloid and Increase in Aβ Oligomers. J. Alzheimers. Dis. 54(3):1047-1059. (2016)
  • Nakamura T, Okamoto I, Sasaki K, Yabuta Y, Iwatani C, Tsuchiya H, Seita Y, Nakamura S, Yamamoto T & Saitou M. A developmental coordinate of pluripotency among mice, monkeys and humans. Nature. 537(7618):57-62 (2016)
  • Okumura N, Sakamoto Y, Fujii K, Kitano J, Nakano S, Tsujimoto Y, Nakamura S, Ueno M, Hagiya M, Hamuro J, Matsuyama A, Suzuki S, Shiina T, Kinoshita S, Koizumi N. Rho kinase inhibitor enables cell-based therapy for corneal endothelial dysfunction. Sci Rep. 6:26113 (2016)
  • Seita Y, Tsukiyama T, Iwatani C, Tsuchiya H, Matsushita J, Azami T, Okahara J, Nakamura S, Hayashi Y, Hitoshi S, Itoh Y, Imamura T, Nishimura M, Tooyama I, Miyoshi H, Saitou M, Ogasawara K, Sasaki E, Ema M. Generation of transgenic cynomolgus monkeys that express green fluorescent protein throughout the whole body. Sci Rep. 6:24868. (2016)
2015
  • Sasaki K, Yokobayashi S, Nakamura T, Okamoto I, Yabuta Y, Kurimoto K, Ohta H, Moritoki Y, Iwatani C, Tsuchiya H, Nakamura S, Sekiguchi K, Sakuma T, Yamamoto T, Mori T, Woltjen K, Nakagawa M, Yamamoto T, Takahashi K, Yamanaka S, Saitou M. Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells. Cell Stem Cell. 17(2):178-94. (2015)
  • Itoh Y, Shichinohe S, Nakayama M, Igarashi M, Ishii A, Ishigaki H, Ishida H, Kitagawa N, Sasamura T, Shiohara M, Doi M, Tsuchiya H, Nakamura S, Okamatsu M, Sakoda Y, Kida H, Ogasawara K. Antimicrob Agents Chemother. Emergence of H7N9 Influenza A Virus Resistant to Neuraminidase Inhibitors in Nonhuman Primates. 59:4962-73. (2015)
  • Iizuka S, Sakurai F, Shimizu K, Ohashi K, Nakamura S, Tachibana M, Mizuguchi H. Evaluation of transduction properties of an adenovirus vector in neonatal mice. Biomed Res Int. 2015:685374 (2015)
2014
  • Moi ML, Takasaki T, Omatsu T, Nakamura S, Katakai Y, Ami Y, Suzaki Y, Saijo M, Akari H, Kurane I. Demonstration of marmosets (Callithrix jacchus) as a non-human primate model for secondary dengue virus infection: high levels of viraemia and serotype cross-reactive antibody responses consistent with secondary infection of humans. J Gen Virol. 95(3): 591-600. (2014)
  • Shimizu K, Sakurai F, Tomita K, Nagamoto Y, Nakamura S, Katayama K, Tachibana M, Kawabata K, Mizuguchi H. Suppression of leaky expression of adenovirus genes by insertion of microRNA-targeted sequences in the replication-incompetent adenovirus vector genome. Mol Ther Methods Clin Dev. 1:14035. (2014)
2013
  • Nakayama M, Shichinohe S, Itoh Y, Ishigaki H, Kitano M, Arikata M, Pham VL, Ishida H, Kitagawa N, Okamatsu M, Sakoda Y, Ichikawa T, Tsuchiya H, Nakamura S, Le QM, Ito M, Kawaoka Y, Kida H, Ogasawara K. Protection against H5N1 highly pathogenic avian and pandemic (H1N1) 2009 influenza virus infection in cynomolgus monkeys by an inactivated H5N1 whole particle vaccine. PLoS One. 8:e82740. (2013)
  • Pham VL, Nakayama M, Itoh Y, Ishigaki H, Kitano M, Arikata M, Ishida H, Kitagawa N, Shichinohe S, Okamatsu M, Sakoda Y, Tsuchiya H, Nakamura S, Kida H, Ogasawara K. Pathogenicity of pandemic H1N1 influenza A virus in immunocompromised cynomolgus macaques. PLoS One. 8:e75910 (2013)
  • Moi ML, Omatsu T, Hirayama T, Nakamura S, Katakai Y, Yoshida T, Saito A, Tajima S, Ito M, Takasaki T, Akari H, Kurane I. Presence of viral genome in urine and development of hematuria and pathological changes in kidneys in common marmoset (Callithrix jacchus) after inoculation with dengue virus. Pathogen. 2:357-363. (2013)
  • Okumura N, Koizumi N, Kay EP, Ueno M, Sakamoto Y, Nakamura S, Hamuro J, Kinoshita S. The ROCK inhibitor eye drop accelerates corneal endothelium wound healing. Invest Ophthalmol Vis Sci. 54:2493-2502. (2013)
2012
  • Omatsu T, Moi ML, Takasaki T, Nakamura S, Katakai Y, Tajima S, Ito M, Yoshida T, Saito A, Akari H, Kurane I. Changes in hematological and serum biochemical parameters in common marmosets (Callithrix jacchus) after inoculation with dengue virus. J Med Primatol. 41:289-296. (2012)
  • Sugimoto C, Nakamura S, Hagen SI, Tsunetsugu-Yokota Y, Villinger F, Ansari AA, Suzuki Y, Yamamoto N, Nagai Y, Picker LJ, Mori K. Glycosylation of simian immunodeficiency virus influences immune-tissue targeting during primary infection, leading to immunodeficiency or viral control. J Virol. 86:9323-9336. (2012)
  • Nishimura M, Nakamura S, Kimura N, Liu L, Suzuki T, Tooyama I. Age-related modulation of γ-secretase activity in non-human primate brains. J Neurochem. 123:21-28. (2012)
  • Arikata M, Itoh Y, Okamatsu M, Maeda T, Shiina T, Tanaka K, Suzuki S, Nakayama M, Sakoda Y, Ishigaki H, Takada A, Ishida H, Soda K, Pham VL, Tsuchiya H, Nakamura S, Torii R, Shimizu T, Inoko H, Ohkubo I, Kida H, Ogasawara K. Memory immune responses against pandemic (H1N1) 2009 influenza virus induced by a whole particle vaccine in cynomolgus monkeys carrying Mafa-A1*052:02. PLoS One. 7:e37220. (2012)
  • Okahara-Narita J, Umeda R, Nakamura S, Mori T, Noce T, Torii R. Induction of pluripotent stem cells from fetal and adult cynomolgus monkey fibroblasts using four human transcription factors. Primates. 53:205-213. (2012)
  • Nakamura S, Tsuchiya H, Okahara N, Nakagawa T, Ohara N, Yamamoto H, Li T, Takeda N, Ogasawara K, Torii R. Epidemiology of Hepatitis E Virus in Indoor-Captive Cynomolgus Monkey Colony. J Vet Med Sci. 57;279-283. (2012)
  • Ueda M, Ageyama N, Nakamura S, Nakamura M, Chambers J, Misumi Y, Mizuguchi M, Shinriki S, Kawahara S, Tasaki M, Jono H, Obayashi K, Sasaki E, Une Y, Ando Y. Aged vervet monkeys developing transthyretin amyloidosis with the human disease-causing Ile122 allele: A valid pathological model of the human disease. Lab Invest. 92:474-484. (2012)
  • Yoshida T, Omatsu T, Saito A, Katakai Y, Iwasaki Y, Iijima S, Kurosawa T, Hamano M, Nakamura S, Takasaki T, Yasutomi Y, Kurane I, Akari H. CD16 positive natural killer cells play a limited role against primary dengue virus infection in tamarins. Arch Virol. 157:363-368. (2012)
  • Morichika J, Iwatani C, Tsuchiya H, Nakamura S, Sankai T, Torii R. Triplet pregnancy in a cynomolgus monkey (Macaca fascicularis) after double embryo transfer. Comp Med. 62:69-72. (2012)
  • Toyoshima Y, Sekiguchi S, Negishi T, Nakamura S, Ihara T, Ishii Y, Kyuwa S, Yoshikawa Y, Takahashi K. Differentiation of neural cells in fetal cerebral cortex of cynomolgus monkeys (Macaca fascicularis). Comp Med. 62:53-60. (2012)
2011
  • Nakamura S, Ueda M, Ageyama N, Ando Y, Torii R. : Transthyretin amyloidosis in aged vervet monkeys, as a candidate for the spontaneous animal model of senile systemic amyloidosis. (Sarantseva S. ed.) INTECH, (Rijeka, Croatia), 181-190, (2011)
  • Omatsu T, Moi ML, Hirayama T, Takasaki T, Nakamura S, Tajima S, Ito M, Yoshida T, Saito A, Katakai Y, Akari H, Kurane I. Common marmoset (Callithrix jacchus) as a primate model of dengue virus infection: development of high levels of viraemia and demonstration of protective immunity. J Gen Virol. 92:2272-2280. (2011)
2010
  • Ushitora M, Sakurai F, Yamaguchi T, Nakamura S, Kondoh M, Yagi K, Kawabata K, Mizuguchi H. Prevention of hepatic ischemia-reperfusion injury by pre-administration of catalase-expressing adenovirus vectors. J Control Release. 142:431-437. (2010)
  • Shimozawa N, Nakamura S, Takahashi I, Hatori M, Sankai T. Characterization of a novel embryonic stem cell line from an intracytoplasmic sperm injection-derived blastocyst in the African green monkey. Reproduction. 139:565-573. (2010)
2009
  • Sakurai F, Nakamura S, Akitomo K, Shibata H, Terao K, Kawabata K, Hayakawa T, Mizuguchi H. Adenovirus serotype 35 vector-mediated transduction following direct administration into organs of nonhuman primates. Gene Ther. 16: 297-302. (2009)