土屋 英明

技術専門職員
経歴
平成2年3月 茨城大学農学部畜産学科卒業
平成5年9月 茨城大学大学院農学研究科生物生産学専攻(修士課程)修了
平成14年3月 熊本大学大学院自然科学研究科物質・生命科学専攻(後期博士課程)修了
平成5年10月 環境庁国立環境研究所動物実験室(財団法人 地球・人間環境フォーラム研究員)
平成7年3月 厚生省国立予防衛生研究所(現:医薬基盤研究所)・筑波医学実験用霊長類センター(財団法人 ヒューマンサイエンス振興財団研究員)
平成12年1月 環境省国立水俣病総合研究センター基礎研究部(科学技術振興事業団 重点研究支援協力員)
平成16年4月 国立大学法人 滋賀医科大学 動物生命科学研究センター 助手
平成19年4月 同 助教
平成21年4月 同 技術専門職員
研究テーマ

ヒト医療研究用モデルザル供給ネットワークの構築(MHC遺伝子統御カニクイザルの計画的室内人工繁殖システムの確立)

論文一覧
2016
  • Sasaki K, Nakamura T, Okamoto I, Yabuta Y, Iwatani C, Tsuchiya H, Seita Y, Nakamura S, Shiraki N, Takakuwa T, Yamamoto T, Saitou M. The Germ Cell Fate of Cynomolgus Monkeys Is Specified in the Nascent Amnion. Dev Cell. 39(2):169-185 (2016)
  • Nakamura T, Okamoto I, Sasaki K, Yabuta Y, Iwatani C, Tsuchiya H, Seita Y, Nakamura S, Yamamoto T & Saitou M. A developmental coordinate of pluripotency among mice, monkeys and humans. Nature. 537(7618):57-62 (2016)
  • Adachi M, Kisu I, Nagai T, Emoto K, Banno K, Umene K, Nogami Y, Tsuchiya H, Itagaki I, Kawamoto I, Nakagawa T, Ogasawara K, Aoki D. Evaluation of allowable time and histopathological changes in warm ischemia of the uterus in cynomolgus monkey as a model for uterus transplantation. Acta Obstet Gynecol Scand. 2016 Jun 22. doi: 10.1111/aogs.12943. [Epub ahead of print]
  • Koyama S, Fukuda K, Watanabe S, Kohara S, Tsuchiya H, Fukuzaki K, Nagano M, Uno Y, Hosoi Y. Development of a new device for artificial insemination in cynomolgus macaques. J Reprod Dev. 2016 Jun 17. [Epub ahead of print]
  • Seita Y, Tsukiyama T, Iwatani C, Tsuchiya H, Matsushita J, Azami T, Okahara J, Nakamura S, Hayashi Y, Hitoshi S, Itoh Y, Imamura T, Nishimura M, Tooyama I, Miyoshi H, Saitou M, Ogasawara K, Sasaki E, Ema M. Generation of transgenic cynomolgus monkeys that express green fluorescent protein throughout the whole body. Sci Rep. 6:24868. (2016)
2015
  • Shiina T, Yamada Y, Aarnink A, Suzuki S, Masuya A, Ito S, Ido D, Yamanaka H, Iwatani C, Tsuchiya H, Ishigaki H, Itoh Y, Ogasawara K, Kulski JK, Blancher A. Discovery of novel MHC-class I alleles and haplotypes in Filipino cynomolgus macaques (Macaca fascicularis) by pyrosequencing and Sanger sequencing: Mafa-class I polymorphism.Immunogenetics. 67(10):563-78. (2015)
  • Sasaki K, Yokobayashi S, Nakamura T, Okamoto I, Yabuta Y, Kurimoto K, Ohta H, Moritoki Y, Iwatani C, Tsuchiya H, Nakamura S, Sekiguchi K, Sakuma T, Yamamoto T, Mori T, Woltjen K, Nakagawa M, Yamamoto T, Takahashi K, Yamanaka S, Saitou M. Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells. Cell Stem Cell. 17(2):178-94. (2015)
  • Itoh Y, Shichinohe S, Nakayama M, Igarashi M, Ishii A, Ishigaki H, Ishida H, Kitagawa N, Sasamura T, Shiohara M, Doi M, Tsuchiya H, Nakamura S, Okamatsu M, Sakoda Y, Kida H, Ogasawara K. Emergence of H7N9 Influenza A Virus Resistant to Neuraminidase Inhibitors in Nonhuman Primates. Antimicrob Agents Chemother. 59(8):4962-73. (2015)
2014
  • Itoh Y, Yoshida R, Shichinohe S, Higuchi M, Ishigaki H, Nakayama M, Pham VL, Ishida H, Kitano M, Arikata M, Kitagawa N, Mitsuishi Y, Ogasawara K, Tsuchiya H, Hiono T, Okamatsu M, Sakoda Y, Kida H, Ito M, Quynh Mai L, Kawaoka Y, Miyamoto H, Ishijima M, Igarashi M, Suzuki Y, Takada A. Protective efficacy of passive immunization with monoclonal antibodies in animal models of H5N1 highly pathogenic avian influenza virus infection. PLoS Pathog. 10(6):e1004192. (2014)
  • Kitano M, Itoh Y, Ishigaki H, Nakayama M, Ishida H, Pham VL, Arikata M, Shichinohe S, Tsuchiya H, Kitagawa N, Kobayashi M, Yoshida R, Sato A, Le QM, Kawaoka Y, Ogasawara K. Efficacy of repeated intravenous administration of peramivir against highly pathogenic avian influenza A (H5N1) virus in cynomolgus macaques. Antimicrob Agents Chemother. 58(8):4795-803. (2014)
  • Kisu I, Kato Y, Tsuchiya H, Kawamoto I, Nakagawa T, Ogasawara K, Hayakawa T, Yamayoshi Y, Iketan O, Mihara M, Banno K, Sato S, Shiina T, Aoki D. Pharmacokinetic Properties of Cyclosporine A after Subcutaneous Injection in Cynomolgus Monkey. Study of International Journal of Pharmacology (2014)
2013
  • Nakayama M, Shichinohe S, Itoh Y, Ishigaki H, Kitano M, Arikata M, Pham VL, Ishida H, Kitagawa N, Okamatsu M, Sakoda Y, Ichikawa T, Tsuchiya H, Nakamura S, Le QM, Ito M, Kawaoka Y, Kida H, Ogasawara K. Protection against H5N1 Highly Pathogenic Avian and Pandemic (H1N1) 2009 Influenza Virus Infection in Cynomolgus Monkeys by an Inactivated H5N1 Whole Particle Vaccine. PLoS One. 8(12), e82740. (2013)
  • Pham VL, Nakayama M, Itoh Y, Ishigaki H, Kitano M, Arikata M, Ishida H, Kitagawa N, Shichinohe S, Okamatsu M, Sakoda Y, Tsuchiya H, Nakamura S, Kida H, Ogasawara K. Pathogenicity of pandemic H1N1 influenza A virus in immunocompromised cynomolgus macaques. PLoS One. 8(9), e75910. (2013)
2012
  • Nakamura S, Tsuchiya H, Okahara N, Nakagawa T, Ohara N, Yamamoto H, Li TC, Takeda N, Ogasawara K, Torii R. Epidemiology of hepatitis E virus in indoor-captive cynomolgus monkey colony. J Vet Med Sci. 74(3), 279-283. (2012)
  • Morichika J, Iwatani C, Tsuchiya H, Nakamura S, Sankai T, Torii R. Triplet pregnancy in a cynomolgus monkey (Macaca fascicularis) after double embryo transfer. Comp Med. 62(1), 69-72. (2012)
2011
  • Yamasaki J, Iwatani C, Tsuchiya H, Okahara J, Sankai T, Torii R. Vitrification and transfer of cynomolgus monkey (Macaca fascicularis) embryos fertilized by intracytoplasmic sperm injection. Theriogenology. 76(1), 33-38 (2011)
2010
  • Kitano M, Itoh Y, Kodama M, Ishigaki H, Nakayama M, Nagata T, Ishida H, Tsuchiya H, Torii R, Baba K, Yoshida R, Sato A, Ogasawara K. Establishment of a cynomolgus macaque model of influenza B virus infection. Virology. 407(2), 178-184. (2010)
  • Miyake T, Soda K, Itoh Y, Sakoda Y, Ishigaki H, Nagata T, Ishida H, Nakayama M, Ozaki H, Tsuchiya H, Torii R, Kida H, Ogasawara K. Amelioration of pneumonia with Streptococcus pneumoniae infection by inoculation with a vaccine against highly pathogenic avian influenza virus in a non-human primate mixed infection model. J Med Primatol. 39(1), 58-70. (2010)
  • Itoh Y, Ozaki H, Ishigaki H, Sakoda Y, Nagata T, Soda K, Isoda N, Miyake T, Ishida H, Okamoto K, Nakayama M, Tsuchiya H, Torii R, Kida H, Ogasawara K. Subcutaneous inoculation of a whole virus particle vaccine prepared from a non-pathogenic virus library induces protective immunity against H7N7 highly pathogenic avian influenza virus in cynomolgus macaques. Vaccine. 8; 28(3), 780-789. (2010)
2009
  • Itoh Y, Ozaki H, Tsuchiya H, Okamoto K, Torii R, Sakoda Y, Kawaoka Y, Ogasawara K, Kida H. A vaccine prepared from a non-pathogenic H5N1 avian influenza virus strain confers protective immunity against highly pathogenic avian influenza virus infection in cynomolgus macaques. Vaccine. 26(4), 562-72. (2009)
  • Kita YF, Hosomichi K, Kohara S, Itoh Y, Ogasawara K, Tsuchiya H, Torii R, Inoko H, Blancher A, Kulski JK, Shiina T. MHC class I A loci polymorphism and diversity in three Southeast Asian populations of cynomolgus macaque. Immunogenetics. 61(9), 635-48. (2009)